When traveling in Alsace, you can reach Strasbourg by various highways:
– from the Paris and Benelux, take the A4 highway (E25). About 4 hours from Paris and 2 hour 15 minutes from Luxembourg.
– from the Switzerland and Lyon, take the A35 highway (E25). About 5 hours from Lyon
– from the north and east likely Germany, take the A5 highway (E35).
Driving into heart of Strasbourg relatively easy although there are a few streets off limits to cars. There are many large garages surrounding the old city if your hotel does not have its own parking facility. Some carparks are more expensive than other, especially for longer stays.
From Strasbourg, you can follow Alsace wine route, which is one of the oldest routes of France and explore wineries near Colmar and Riquewihr.